Verapamil and Its Role in Diabetes

Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis development of type 1 diabetes, with prospective increased risk for developing micro- macrovascular complications. In this regard, orally administrated verapamil, calcium channel antagonist, usually intended use as an anti-arrhythmic drug, has previously shown potential beneficial effects on preservation new-onset diabetes. Furthermore, observational data suggest reduced 2 diabetes development. The underlying pathophysiological mechanisms are not well investigated remain widely inconclusive. aim narrative review was to detail verapamil promoting endogenous function, potentially eligible early treatment summarize existing evidence its effect glycemia individuals